Food Allergy Clinical Studies

Efficacy of allergen-specific immunotherapy for peanut allergy: a meta-analysis of randomized controlled trials.

https://www.ncbi.nlm.nih.gov/pubmed/24717795

Other Studies:

Safety Information Regarding Allergy Drops (Sublingual Immunotherapy)


JAMA Network-Sublingual Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and Asthma

http://waojournal.biomedcentral.com/articles/10.1186/1939-4551-7-6

World Allergy Position Statement on Sublingual Therapy
http://waojournal.biomedcentral.com/articles/10.1186/1939-4551-7-6

Sublingual immunotherapy: current concepts for the U.S. practitioner.
Int Forum Allergy Rhinol. http://www.ncbi.nlm.nih.gov/pubmed/25182357#
2014 Sep;4 Suppl 2:S55-9. doi: 10.1002/alr.21388.

JAMA Network-Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review
http://www.ncbi.nlm.nih.gov/pubmed/23532243#
2013 Mar 27;309(12):1278-88. doi: 10.1001/jama.2013.2049.

Clinical considerations in the use of sublingual immunotherapy for allergic rhinitis.
Am J Rhinol Allergy. http://www.ncbi.nlm.nih.gov/pubmed/25785750#
2015 Mar;29(2):106-14. doi: 10.2500/ajra.2015.29.4148.

Safety Studies

Aboshady et al.
Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240478/pdf/ceo-7-241.pdf


Andre et al.
Safety of sublingual-swallow therapy in children and adults.
Intl Arch Allergy Immunol.
2000 Mar; 121(3):229-34
http://www.ncbi.nlm.nih.gov/pubmed/10729782
Review of 8 studies containing 690 patients. No serious reactions.


Di Rienzo et al.
Grass pollen specific sublingual/swallow immunotherapy in children: open controlled comparison among different treatment protocols. Allergologia et Immunopathogia
1999. 27(3): 145-51
http://www.ncbi.nlm.nih.gov/pubmed/10431100
268 children (age 2-15 years), approximately 96,000 doses of allergy drops

  • No serious or life-threatening reactions
  • Adverse events rate: 0.83 per 1000 doses (3% of children in the study)
  • 7 adverse events requiring no treatment (including stomach pain, itchy eyes, nasal congestion)
  • 1 case of hives which required treatment with an antihistamine


Lombardi et al.
Safety of sublingual immunotherapy with monomeric allergoid in adults: multicenter post-marketing surveillance study.
Allergy, 2001.56(10): 989-92.
http://www.ncbi.nlm.nih.gov/pubmed/11576079

198 patients, 32,800 doses of allergy drops

  • Adverse event rate was 0.52 per 1000 doses
  • Most required no treatment
  • Dose adjustment was needed in 4 patients (2 for stomach pain, 2 for hives)
  • 2 patients needed antihistamine (1 for hives, 1 for itchy eyes)


Pajno et al.
Efficacy of sublingual immunotherapy in asthma and eczema.
Chemical Immunology & Allergy, 2003. 82: 77-88.
http://www.ncbi.nlm.nih.gov/pubmed/12947994
344 children (age 5-12 years) undergoing allergy therapy for allergic asthma

  • No serious reactions
  • 10% had an adverse reaction
  • Most common side effects were tiredness and/or headache
  • Most adverse events occurred during initial dose escalation
  • Wheezing in 2 patients (one was “mild”, the other was “moderate”)
  • Treatment stopped in 5 patients as a precaution (1 for nasal allergy symptoms, 2 for hives, 2 for wheezing)


Curr Med Res Opin.
Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections.
http://www.ncbi.nlm.nih.gov/pubmed/25753228#
2015 Mar 31:1-3. [Epub ahead of print]

Efficacy Studies

Aboshady et al.
Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240478/pdf/ceo-7-241.pdf


Leatherman et al.
Sublingual immunotherapy: past, present, paradigm for the future? A review of the literature.
Otolayngol Head Neck Surg 2007; 136:S1-20
http://www.ncbi.nlm.nih.gov/pubmed/17321336
Review of 36 previous studies

  • 30 out of 36 studies showed efficacy in reduction of allergy symptoms, decrease in medication use or both.
  • Efficacy shown for both seasonal and perennial allergens


Wilson et al.
Sublingual immunotherapy or allergic rhinitis: systematic review and meta-analysis
.
Allergy 2005; 60: 4-12
http://www.ncbi.nlm.nih.gov/pubmed/15575924
Review of 22 previous double-blinded placebo controlled trials (adults and/or children)

  • Significant reduction in symptom and medication scores
  • Efficacy clearly shown for combined ages and adults alone but not for children alone
  • Smaller number of studies evaluating children


Penagos et al.
Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3-18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials.
Annals All Asth Immunol. 97(2): 141-8, 2006 Aug.
http://www.ncbi.nlm.nih.gov/pubmed/16937742 
10 previous studies of children receiving SLIT were reviewed

  • Significant improvement in symptom scores and medication scores
  • Subset analysis showed significant improvement for pollens only and for treatment duration of more than 18 months.
  • Dust mites fell short of significance, but studies with higher doses did show significant improvement.


Radulovic et al.
Sublingual immunotherapy for allergic rhinitis (including hay fever) 
Cochrane Review February 2011.
http://summaries.cochrane.org/CD002893/sublingual-immunotherapy-for-allergicrhinitis-including-hay-fever
Review of 60 previous studies

  • Significant improvement in symptom and medication in patients treated with sublingual drops
  • No serious adverse reactions

Calderon et al.
Sublingual immunotherapy (tablets, spray, or drops under the tongue) to treat inflammation of the conjunctiva due to allergy. 
Cochrane Review July 2011.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0014569/
Review of 42 previous studies

  • Sublingual therapy can reduce symptoms of allergic conjunctivitis (itchy/watery eyes)


Allergy Asthma Immunol Res. http://www.ncbi.nlm.nih.gov/pubmed/25729618# 2015 Mar;7(2):118-23. doi: 10.4168/aair.2015.7.2.118. Epub 2014 Oct 30. Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitized to House Dust Mites.


Efficacy of sublingual specific immunotherapy in patients with respiratory allergy to Alternaria alternata: a randomised, assessor-blinded, patient-reported outcome, controlled 3-year trial.
https://www.ncbi.nlm.nih.gov/pubmed/21050060

Studies Comparing Allergy Drops to Allergy Shots

There have been a number of studies comparing allergy shots and drops. Some have shown that drops are better at treating nasal allergies, while others have shown that shots are better. Most have shown equal results between the two options. The opinion of Texan Allergy & Sinus Center is that allergy shots and allergy drops have roughly the same effectiveness at treating allergies, and that allergy drops are safer than shots (though both are very safe if proper precautions are taken).

Here are a few references of studies comparing shots and drops:

More Information

If you have any questions about allergy drop costs or treatment, contact us online, or give us a call.